by Steffen Härting
by Moritz Mercker
by Moritz Mercker
by Steffen Härting

ECMTB 2014

Minisymposium "Mathematical modelling of stem cell renewal and differentiation"
Anna Marciniak-Czochra (University of Heidelberg)
There is a clear evidence that divergent fates of the progeny cells are determined in mitosis by a process called asymmetric cell division. It results in two daughter cells that adopt distinct fates. Control of the decision to divide symmetrically or asymmetrically via intrinsic or extrinsic mechanisms is essential for stable and efficient dynamics of tissue homeostasis and regeneration. Disturbing such regulation may lead to destabilisation and, in turn, to cancer development. Precise experimental data on regulation of asymmetric cell divisions and its role in tissue dynamics are so far elusive. Mathematical modelling is a powerful technique to address new questions and paradigms in model systems and to provide quantitative insights into cell kinetics, fate determination and development of the whole cell population This minisymposium is designed to provide an overview of mathematical approaches to understand fate determination, clonal evolution and prediction of short- and long-term dynamics of stem cells. Specifically, we will focus on the models of normal and leukemic hematopoiesis. The lectures given in the minisymposium will provide recent results on deterministic and stochastic models of cell self-renewal and differentiation in hierarchically organised tissues.
Time Schedule
Monday, June 16, 2014
Room F31 in the Maths Department
17:00 - 17:40: Romain Ivinec (INRA UMR6175, Nouzilly, France) Stochastic gene expression model and structured nonlinear cell population model (Abstract)
17:40 - 18:20: Frederik Ziebell (DKFZ and Institute of Applied Mathematics, University of Heidelberg, Germany) Modelling of Neural Stem Cell Dynamics in the Adult Hippocampus (Abstract)
18:20 - 19:00: Thomas Stiehl (Institute of Applied Mathematics, University of Heidelberg, Germany) Clonal Selection and Stem Cell Dynamics in Acute Leukemias (Abstract)